A/G Ratio: The ratio of albumin to globulin (A/G ratio) is calculated from values obtained by direct measurement of total protein and albumin. It represents the relative amounts of albumin and globulins. A low A/G ratio may reflect overproduction of globulins (such as seen in multiple myeloma or autoimmune diseases) or underproduction of albumin (such as occurs with cirrhosis) or selective loss of albumin from the circulation (as occurs with nephrotic syndrome). A high A/G ratio suggests underproduction of immunoglobulins (as may be seen in some genetic deficiencies and in some leukemias). More specific tests, such as albumin, liver enzyme tests, and serum protein electrophoresis must be performed to make an accurate diagnosis.